Columbia University

Heffner Biomedical Imaging Lab

Journal papers


J. Yang, X. Feng, A. F. Laine and E. D. Angelini, "Characterizing Alzheimer's Disease With Image and Genetic Biomarkers Using Supervised Topic Models," in IEEE Journal of Biomedical and Health Informatics, vol. 24, no. 4, pp. 1180-1187, April 2020. (PDF)


M. Wang, C. P. Aaron, J. Madrigano, E. A. Hoffman, E Angelini, J. Yang, A. Laine, T. M. Vetterli, P. L. Kinney, P. D. Sampson, L. E. Sheppard, A. A. Szpiro, S. D. Adar, K. Kirwa, B. Smith, D. J. Lederer, A. V. Diez-Roux, S. Vedal, J. D. Kaufman, R. G. Barr, “Association between long-term exposure to ambient air pollution and change in quantitatively assessed emphysema and lung function”, JAMA, Vol. 322, No. 6, pp. 546-556, 2019. (PDF)
J. Yang, X. Feng, A. Laine, E. Angelini, “Characterizing Alzheimer's disease with image and genetic biomarkers using supervised topic models”, IEEE Journal of Biomedical and Health Informatics. 2019. (PDF)
E. Roccia, A. Mikhno , R. T. Ogden, J. J. Mann, A. F. Laine, E. D. Angelini, F. Zanderigo, “Quantifying brain [18F]FDG uptake noninvasively by combining medical health records and dynamic PET imaging data”, IEEE Journal on Biomedical and Health Informatics, 2019. (PDF)
Y. Ling, W. Meiniel, R. Singh-Moon, E. Angelini, J.-C. Olivo-Marin, C. P. Hendon, “Compressed sensing-enabled phase- sensitive swept-source optical coherence tomography”, Optics Express, Vol. 27, No. 2, pp. 855-871, 2019. (PDF)


C. Aaron, J. Schwartz, E. Hoffman, E. Angelini, J. Austin, M. Cushman, D. Jacobs Jr, J. Kaufman, A. Laine, L. Smith, J. Yang, K. Watson, R. Tracy, R. Barr. "A Longitudinal Cohort Study of Aspirin Use and Progression of Emphysema-like Lung Characteristics on CT Imaging: The MESA Lung Study." Chest (2017). (Link)



J. Guo, G. Zhu, Y. Sun, A. Laine, S. Small, D. Rothman, "In vivo detection and automatic analysis of GABA in the mouse brain with MEGA‐PRESS at 9.4 T." NMR in Biomedicine 31, no. 1 (2018). (Link)



A. Lorsakul, G.Fakhri, W. Worstell, J. Ouyang, Y. Rakvongthai, A. F. Laine, Q Li, "Numerical observer for atherosclerotic plaque classification in spectral computed tomography." Journal of Medical Imaging,3(3) pp: 035501-035501, 2016. (Link)

W. Lee, S. Lisanby, A. Laine, A. Peterchev, "Minimum Electric Field Exposure for Seizure Induction with Electroconvulsive Therapy and Magnetic Seizure Therapy". Neuropsychopharmacology. 2016. (Link)

M. Akay, G. Coatrieux, Y. Hao, D. Fotiadis, A. Laine, B. Lo, K. Nikita, N. Noury, J. Rodrigues, M. Wang. "Guest Editorial: MobiHealth 2014, IEEE HealthCom 2014, and IEEE BHI 2014." IEEE Journal of Biomedical and Health Informatics, no.3: 731-732, 2016. (Link)

A. Roy, S. Conjeti, S. Carlier, P. Dutta, A. Kastrati, A. Laine, N. Navab, A. Katouzian, D. Sheet. "Lumen Segmentation in Intravascular Optical Coherence Tomography Using Backscattering Tracked and Initialized Random Walks." IEEE journal of biomedical and health informatics, no.2: 606-614, 2016. (Link)

D. Lesage, E. D. Angelini, G. Funka-Lea, I. Bloch, "Adaptive particle filtering for coronary artery segmentation from 3D CT angiograms", Computer Vision and Image Understanding, Vol. 151, pp. 29-46, 2016. (Link)


F. Vicario, A. Albanese, N. Karamolegkos, D. Wang, A. Seiver, N. W. Chbat, "Noninvasive Estimation of Respiratory Mechanics in Spontaneously Breathing Ventilated Patients: A Constrained Optimization Approach.", IEEE Transactions on Biomedical Engineering, Vol. 63, No 4, pp:775-787. (Link)

A. Mikhno, F. Zanderigo, R. T. Ogden, J. J. Mann, E. D. Angelini, A. F. Laine, R. V. Parsey, "Toward Noninvasive Quantification of Brain Radioligand Binding by Combining Electronic Health Records and Dynamic PET Imaging Data", IEEE Journal of Biomedical and Health Informatics, Vol. 19, No. 14, pp. 1271-1282, 2015. (Link)

G. David, J.-L. Robert, B. Zhang, A. F. Laine, "Time domain compressive beam forming of ultrasound signals", The Journal of the Acoustical Society of America, Vol. 13, No 5, 2015. (Link)

W. H. Lee, S. H. Lisanby, A. F. Laine, and A. V. Peterchev, *Electric field model of transcranial electric stimulation in nonhuman primates: correspondence to individual motor threshold", IEEE Transaction on Biomedical Engineering, Vol. 62, No. 9, pp. 2095-2105, 2015  (Cover Article and Featured in Research Highlights). (Link)


David Elad, Pavel Kozlovsky, Omry Blum, Andrew F. Laine, Ming Jack Po, Eyal Botzer, Shaul Dollberg, Mabel Zelicovich, "Biomechanics of milk extraction during breast-feeding", Proceedings of the National Academy of Sciences (PNAS), 2014. (Link)

S. Audiere, E. Angelini, L. Sandrin, M. Charbit, "Maximum Likelihood Estimation of Shear Wave Speed in Transient Elastography", IEEE Transactions on Medical Imaging, 2014. (Link)

Y. Hame, E. Angelini, E. Hoffman, G. Barr, A. F Laine, "Adaptive quantification and longitudinal analysis of pulmonary emphysema with a hidden Markov measure field model", IEEE Transactions on Medical Imaging, Vol. 33, No.7, pp. 1527 - 1540, 2014. , 2014. (Link)

A.M Brickman, U.A Khan, F. Provenzano, Y. L.K., Suzuki W., H. Schroeter , M. Wall , R.P, Sloan,  S. A Small, "Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults", Nature Neurosciences, 2014. (Link)


Fei Wang, Noah Lee, Jianying Hu, Jimeng Sun, Shahram Ebadollahi, Andrew F Laine "A Framework for Mining Signatures from Event Sequences and Its Applications in Healthcare Data", IEEE Transactions on Pattern Analysis and Machine Intelligence, 2013. (Link)


Won Hee Lee, Z. D. Deng, T. S. Kim, S. H. Lisanby, A. V. Peterchev, Andrew F Laine, "Regional electric field induced by electroconvulsive therapy in a realistic finite element head model: influence of white matter anisotropic conductivity", NeuroImage, vol. 59, no. 3, pp. 2110-2123, 2012. (Link)


Amin Katouzian, Stephane Carlier, Jasjit Suri, Nassir Navab, Andrew F Laine, Elsa Angelini "A State of The Art Review on Segmentation Algorithms in Intravascular Ultrasound (IVUS) Images", IEEE Transactions on Information Technology in BioMedicine vol. 16, No 5, pp. 823 – 834, 2012. (Link)



Amin Katouzian, Athanasios Karamalis, Abouzar Eslami, Elisa Konofagou, Babak Baseri, Stephane Carlier, Andreas Koenig, Nassir Navab, Andrew Laine "Iterative Self-Organizing Atherosclerotic Tissue Labeling in Intravascular Ultrasound Images and Comparison with Virtual Histology", IEEE Transactions on Biomedical Engineering, 2012. (Link)




Xin (Sheena) Liu, C. Imielinska, J. Kender, Andrew F Laine "Automatic Misalignment Correction of Neuroimages using Surface Symmetry Priors", Journal of Neuroimaging, vol. 21, doi: 10.1111/j.1552-6569.2011.00577.x, 2011. (Link)


Jian Chen, J. Tian, Noah Lee, J. Zheng, R. Smith, Andrew F Laine "A Partial Intensity Invariant Feature Descriptor for Multimodal Retinal Image Registration", IEEE Transactions of Biomedical Engineering, vol. 57, no. 7, pp. 1707-1718, 2010. (Link)


R. Smith, M. A. Sohrab, N. Pumariega, Y. Chen, Jian Chen, Noah Lee, Andrew F Laine "Dynamic Soft Drusen Remodelling in Age-Related Macular Degeneration", Br. J. Ophthalmol., vol. 94, no. 12, pp. 1618–1623, 2010. (Link)



Ting Song, Vivian Lee, Q Chen, H. Rusinek, Andrew F Laine, "An Automated Three Dimensional plus Time Registration Framework for Dynamic MR Renography ", J Visual Communication and Image Representation, vol. 21, no. 1, pp. 1-8, 2010. (Link)




Xin (Sheena) Liu, "Symmetry and Asymmetry Analysis and its Implications to Computer Aided Diagnosis", Journal of Biomedical Informatics, vol. 42, no. 6, pp. 1056-1064, 2009. (Link)
Noah Lee, Andrew F Laine, G. Marquez, J. M. Levsky, J. K. Gohagan, "Potential of Computer-Aided Diagnosis to Improve CT Lung Cancer Screening", IEEE Reviews in Biomedical Engineering, vol. 2, pp. 136-146, 2009. (Link)
Andrew F Laine "In the Spotlight: Biomedical Imaging", IEEE Reviews in Biomedical Engineering, vol. 2, pp. 6-8, 2009. (Link)
Qi Duan, Elsa Angelini, Andrew F Laine "Surface Function Actives", J. Vis. Commun. Image R., vol. 20, no. 7, pp. 478-490, 2009. (Link)
R. Bansal, L. H. Staib, Andrew F Laine, D. Xu, J. Liu and B. S. Peterson, "Calculation of the Confidence Intervals for Transformation Parameters in the Registration of Medical Images", Medical Image Analysis, vol. 13, no. 2, pp. 215-233, 2009. (Link)
R. Smith, N.L. Gomes, G. Barile, M. Busuioc, Noah Lee, Andrew F Laine "Lipofuscin & Autofluorescence Metrics in progressive STGD", Invest. Ophthalmol. Vis. Sci., vol. 50, pp. 3907-3914, 2009. (Link)
Ting Song, Andrew F Laine, Q. Chen, H. Rusinek, B. Louisa, R. Lim, L. Gerhard, R. Kroeker, Vivian Lee, "Optimal K-Space Sampling for Dynamic Contrast-Enhanced MR Imaging with an Application to MR Renography", Journal of Magnetic Resonance in Medicine, vol. 61, issue 5, pp. 1242-1248, 2009. (Link)


Andrew F. Laine "In the Spotlight: Biomedical Imaging", IEEE Reviews in Biomedical Engineering, vol. 1, pp. 4-7, 2008 (Link)

Qi Duan, Elsa Angelini, S. Herz, C. Ingrassia, K. Costa, J. Holmes, Shunichi Homma, Andrew F Laine "Region-Based Endocardium Tracking on Real-Time Three-Dimensional Ultrasound", Ultrasound in Medicine and Biology, Vol. 35, No. 2, pp. 256-265, 2008. (Link)
A. R. Kherlopian, Ting Song, Qi Duan, Matt Neimark, Ming Jack Po, J. K. Gohagan, Andrew F Laine "A review of imaging techniques for systems biology", BMC Systems Biology, vol. 2, no. 74, pp. 1-18, 2008. (Link)
R. Bansal, L. H. Staib, D. Xu, J. Royal, and B. S. Peterson "Using Perturbation Theory to Compute the Morphological Similarity of Diffusion Tensors", IEEE Transactions on Medical Imaging, vol. 27, issue 5, pp. 589-607, 2008. (Link)
D. A. Wilson, J. Mocco, A. L. D\'Ambrosio, R. Komotar, Jr., J. Zurica, C. P. Kellner, D. K. Hahn, E. S. Connolly, C. Imielinska, E. J. Heyer, Xin (Sheena) Liu "Post-Carotid Endarterectomy Neurocognitive Decline is Associated with Cerebral Blood Flow Asymmetry on Post-Operative Magnetic Resonance Perfusion Brain Scans", J. of Neurological Research; vol. 30, no. 3, pp. 302-6, 2008. (Link)
A. Konstas, J. Choi, J. Pile-Spellman, Matt Neimark, Andrew F Laine "Brain cooling maintenance with cooling cap following induction with intracarotid cold saline infusion: A quantitative model", Journal of Theoretical Biology, Vol. 253, No. 2, pp. 333-344, 2008. (Link)
C. Imielinska, W. S. Millar, E. S. Connolly, A. L. D’Ambrosio, Xin (Sheena) Liu, Andrew F Laine, Felipe Pigna, Hector German Oesterheld, Manuel Mujica Lainez "Asymmetry Analysis in Rodent Cerebral Ischemia Models", Academic Radiology, vol. 15, no. 9, pp. 1181-1197, 2008. (Link)
A. Konstas, J. Choi, J. Pile-Spellman, Matt Neimark, Andrew F Laine "Integration of jugular venous return and circle of Willis in a theoretical human model of selective brain cooling", Journal of Applied Physiology, Vol. 103, pp. 1837-1847, 2007. (Link)
A. Konstas, J. Pile-Spellman, Matt Neimark, Andrew F Laine "A theoretical model of selective cooling using intracarotid cold saline infusion in the human brain", Journal of Applied Physiology, Vol. 102, pp. 1329–1340, 2007. (Link)
Elsa Angelini, B. Mensh, Andrew F Laine, Ting Song "Brain MRI Segmentation with Multiphase Minimal Partitioning: A Comparative Study", International Journal of Biomedical Imaging, vol. 2007, article id 10526, pp. 1-15, 2007. (Link)


A. Georgiev, S. Vorobiev, W. Edstrom, J. Hunt, P. Allen, Ting Song, Andrew F Laine "Automated streak-seeding with micromachined silicon tools", Acta Crystallographica Section D, Vol. 62, Part 9, pp. 1039-1045, 2006. (Link)


G. Pearson, J. Holmes, Qi Duan, Andrew F Laine, Shunichi Homma, Elsa Angelini "Segmentation of Real-Time Three-Dimensional Ultrasound for Quantification of Ventricular Function: A Clinical Study on Right and Left Ventricles", Ultrasound in Medicine & Biology, vol. 31, no. 9, pp: 1143-68, 2005. (Link)
C. Imielinska, J. Rosiene, M. E. Sughrue, R. J. Komotar, J. Mocco, E. R. Ransom, A. Lignelli, B. E. Zacharia E. S. Connolly Jr., and A. L. D’Ambrosio, Xin (Sheena) Liu "Toward Objective Quantification of Perfusion-weighted Computed Tomography in Subarachnoid Hemorrhage: Quantification of Symmetry and Automated Delineation of Vascular Territories", Journal of Academic Radiology, vol. 12, no. 7, pp. 874-87, 2005. (Link)


Ralf Mekle, Andrew F Laine, Edward Wu "Combined MR Data Acquisition of Multicontrast Images Using Variable Acquisition Parameters and K-Space Data Sharing", IEEE Transactions on Medical Imaging, Vol. 22, No. 7, pp. 806-823, 2003. (Link)
M. Unser, A. Aldroubi, Andrew F Laine "Wavelets in Medical Imaging", IEEE Transactions on Medical Imaging, Vol. 22, No. 3, pp. 285-288, 2003. (Link)
Jerome Kalifa, Andrew F Laine, Peter Esser "Regularization in Tomographic Reconstruction Using Thresholding Estimators", IEEE Transactions on Medical Imaging, Volume: 22 Issue: 3, March 2003 pp: 351-359, 2003. (Link)


L. M. Fayad, Y. M. Berkmen, G. D. Pearson, B. Freedman, R. Van Heertum, Andrew F Laine, Yingpen Jin "Chest CT Window Settings with Multiscale Adaptive Histogram Equalization: Pilot Study", Radiology, Vol. 223, No. 3, pp. 845-852, 2002. (Link)


S. Takuma, J. W. Holmes, Elsa Angelini, Shunichi Homma, Andrew F Laine "LV Volume Quantification via Spatiotemporal Analysis of Real-Time 3-D Echocardiography", IEEE Transactions on Medical Imaging, Vol. 20, No. 6, pp. 457-469, 2001. (Link)
J. W. Lin, R. R. Sciacca, R. L. Chou, S. R. Bergmann, Andrew F Laine "Quantification of Myocardial Perfusion in Human Subjects Using 82Rb and Wavelet-Based Noise Reduction", Journal of Nuclear Medicine, Vol. 42, No. 2, pp. 201-208, 2001. (Link)
J. W. Lin, O. Akinboboye, S. R. Bergmann, Andrew F Laine "Use of Wavelet Transforms in Analysis of Time-Activity Data from Cardiac PET", Journal of Nuclear Medicine, Vol. 42, pp. 194-200, 2001. (Link)
J. W. Lin, S. R. Bergmann, Andrew F Laine "Improving PET-Based Physiological Quantification Through Methods of Wavelet Denoising", IEEE Transactions on Biomedical Engineering, Vol. 48, No. 2, pp. 202-212, 2001. (Link)


Andrew F Laine "Wavelets in temporal and spatial processing of biomedical images", Annul Review in Biomedical Engineering, Vol. 2, pp. 511–550, 2000. (Link)


C. M. Chang, Andrew F Laine "Coherence of Multiscale Features for Enhancement of Digital Mammograms", IEEE Transactions on Information Technology in Biomedicine, Vol. 3, No. 1, pp. 32-46, 1999. (Link)
D. Ioannoua, W. Huda, Andrew F Laine "Circle recognition through a 2D Hough Transform and radius histogramming", Image and Vision Computing, Vol. 17, pp. 15-26, 1999. (Link)


X. Zong, E. A. Geiser, Andrew F Laine "Speckle Reduction and Contrast Enhancement of Echocardiograms via Multiscale Nonlinear Processing", IEEE Transactions on Medical Imaging, Vol. 17, No. 4, pp. 532-540, 1998. (Link)


B. Kalman, W. Reinus, S. Kwasny, L. Kotner, Andrew F Laine "Prescreening Entire Mammograms for Masses with Artificial Neural Networks: Preliminary Results", Academic Radiology, vol. 4, no. 6, pp. 405-414., 1997. (Link)


J. Fan, Andrew F. Laine "Frame Representations for Texture Segmentation", IEEE Transactions on Image Processing, Vol. 5, No. 5, pp. 771-780, 1996 (Link)
D. Ioannon, E.T. Dugan, Andrew F. Laine "On the uniqueness of the representation of a convex polygon by its Hough transform", Pattern Recognition Letters, Vol. 17, No. 12, pp. 1259-1264, 1999 (Link)


J. Fan, Yuhai Wang, Andrew F. Laine "Wavelets for Contrast Enhancement of Digital Mammography", IEEE Engineering in Medicine and Biology Magazine, Vol. 14, Issue 5, pp. 536-550, 1995 (Link)

R.A. Kiltie, J. Fan, Andrew F. Laine "A Wavelet-Based Metric for Visual Texture Discrimination with Applications in Evolutionary Ecology", Mathematical Biosciences, Vol. 126, No. 1, pp. 21-39, 1995 (Link)

P. Wunsch, Andrew F. Laine "Wavelet Descriptors for Multiresolution Recognition of Handprinted Characters", Pattern Recognition, Vol. 28, No. 8, pp. 1237-1249, 1995 (Link)

W. Huda, B.G. Steinbach, J.C. Honeyman, Andrew F. Laine, "Mammographic Image Processing using Wavelet Processing Techniques", European Radiology, Vol. 5, pp. 518-523, 1995 (Link)


S. Schuler, J. Fan, W. Huda, Andrew F. Laine "Mammographic Feature Enhancement by Multiscale Analysis", IEEE Transactions on Medical Imaging, Vol. 13, No. 4, pp. 725-752, 1994 (Link)


J. Fan, Andrew F. Laine "Texture classification by Wavelet Packet Signatures", IEEE Transactions on Pattern Analysis and Machine Intelligence, Vol. 15, No. 11, pp. 1186-1191, 1993 (Link)

S. Schuler, V. Girish, Andrew F. Laine "Orthonormal Wavelet Representation for Recognizing Complex Annotations", Machine Vision and Applications, An International Journal, Vol. 6, No. 2-3, pp. 110-123, 1993 (Link)


R.A. Kiltie, Andrew F. Laine "Visual Textures, Machine Vision, and Animal Camouflage", Trends in Ecology and Evolution, Vol. 7, No. 5, pp. 163-166, 1992 (Link)


G.C. Roman, Andrew F. Laine "A Parallel Algorithm for Incremental Stereo Matching on SIMD Machines", IEEE Transactions on Robotics and Automation, Vol. 7, No. 1, pp. 123-124, 1991 (Link)
B. Kalman, S. Pollack, J. Posdamer, S. Reichenbach, Andrew F. Laine "Defense Mapping Goes to School: An Educational Model for Automation", Computer Graphics World, Vol. 8, No. 12, pp. 27-31, 1985 (Link)